abstract：:A pilot case-control study on bladder cancer, with population-based controls matched for each of 74 cases, has been conducted in two industrial areas of Southern Belgium in order to analyze the influence of tobacco use and occupation. Observed bladder cancer risk for smokers is more than 5 times higher than that for n...

journal_title：International journal of cancer

authors： Schifflers E,Jamart J,Renard V

更新日期：1987-03-15 00:00:00

abstract：:A previously published case-control study of agricultural risk factors involved male cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases (ICD). This study has been expanded with the inclusion of cases registered under ICD code 200, and additional controls. The expa...

journal_title：International journal of cancer

authors： Pearce NE,Sheppard RA,Smith AH,Teague CA

更新日期：1987-02-15 00:00:00

abstract：:The effects of DL-alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ornithine decarboxylase, on the growth of experimental mouse B16-F10 melanoma cells were investigated. DFMO (3%) in drinking water was administered to B16-F10 melanoma-bearing mice. At 24 days, B16-F10 melanomas in DFMO-fed mi...

journal_title：International journal of cancer

authors： Kubota S,Ohsawa N,Takaku F

更新日期：1987-02-15 00:00:00

abstract：:By rosetting with SRBC coupled to rabbit-anti-human IgM, the surface IgM-negative cells of human fetal bone marrow were enriched, and subsequently infected and transformed by Epstein-Barr virus (EBV). Single clones of the transformed cells were obtained. Ninety percent of the resulting cell clones were surface-immunog...

journal_title：International journal of cancer

authors： Ernberg I,Falk K,Hansson M

更新日期：1987-02-15 00:00:00

abstract：:Monoclonal antibody (MAb) B72.3 has been previously shown, by in vitro assays, to have a high degree of specificity for carcinomas of the colon, ovary and breast versus normal adult tissues. B72.3 IgG was labelled with 131I and injected i.v. into 20 patients with known or suspected colorectal cancer. All patients subs...

journal_title：International journal of cancer

authors： Esteban JM,Colcher D,Sugarbaker P,Carrasquillo JA,Bryant G,Thor A,Reynolds JC,Larson SM,Schlom J

更新日期：1987-01-15 00:00:00

abstract：:We have established 3 new EBV-negative cell lines, designated Sc-1, Ri-1 and Ci-1, from patients with B-cell lymphoma/leukemia. We characterized them by cytogenetics and by study of surface membrane antigens with a panel of monoclonal antibodies (MAbs), surface and cytoplasmic immunoglobulin (Ig) expression and Ig hea...

journal_title：International journal of cancer

authors： Th'ng KH,Garewal G,Kearney L,Rassool F,Melo JV,White H,Catovsky D,Foroni L,Luzzatto L,Goldman JM

更新日期：1987-01-15 00:00:00

abstract：:Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to ...

journal_title：International journal of cancer

authors： Trichopoulos D,Day NE,Kaklamani E,Tzonou A,Muñoz N,Zavitsanos X,Koumantaki Y,Trichopoulou A

更新日期：1987-01-15 00:00:00

abstract：:The pharmacokinetics of methotrexate (MX) and 7-OH methotrexate (MXOH) was studied in 18 cancer patients treated with 6-hr intravenous (i.v.) infusion of 100 mg/kg (A), 80 mg/kg preceded by 20 mg/kg i.v. loading dose (B), and 70 mg/kg preceded by 30 mg/kg i.v. loading dose (C). Simultaneous analysis of MX and MXOH was...

journal_title：International journal of cancer

authors： el-Yazigi A,Amer M,Al-Saleh I,Martin C

更新日期：1986-12-15 00:00:00

abstract：:Antibodies to HTLV-I have been detected in sera from 15 (2.0%) of 736 adult blood-donors in Nigeria, in 4 (20.0%) of 20 patients with chronic lymphatic leukaemia, 3 (10.0%) of 30 with non-Hodgkin's lymphoma, one of 12 with Burkitt's lymphoma and one of 7 with acute lymphoblastic leukaemia. The frequency of positivity ...

journal_title：International journal of cancer

authors： Fleming AF,Maharajan R,Abraham M,Kulkarni AG,Bhusnurmath SR,Okpara RA,Williams E,Akinsete I,Schneider J,Bayer H

更新日期：1986-12-15 00:00:00

abstract：:Cell lines established from T-cell leukemias have recently been reported to exhibit a chromosome translocation t(8;14) involving proto-oncogene c-myc and the gene of the T-cell receptor alpha-chain(TcR-alpha). In this work, we have studied a case of T-cell leukemia presenting a t(8;14)(q24;q11) translocation that was ...

journal_title：International journal of cancer

authors： Mathieu-Mahul D,Sigaux F,Zhu C,Bernheim A,Mauchauffe M,Daniel MT,Berger R,Larsen CJ

更新日期：1986-12-15 00:00:00

abstract：:Rabbit V2 carcinoma cells and normal rabbit skin fibroblasts produced cysteine proteinases with properties similar to those of purified rabbit liver cathepsin B. Both cell types secreted into the culture medium enzymes with an apparent Mr of 43,000, which reacted with synthetic substrates commonly used for cathepsin B...

journal_title：International journal of cancer

authors： Baici A,Knöpfel M

更新日期：1986-11-15 00:00:00

abstract：:The selective targets for HTLV-III/LAV, the causal infectious agent of AIDS and AIDS-related complex (ARC), are T4 cells, apparently because the virus receptor is associated with T4 antigen determinants. This accounts for T4 cell depletion in AIDS and for a decrease of IL-2 production by AIDS peripheral blood lymphocy...

journal_title：International journal of cancer

authors： Fouchard M,Reveil B,Mbayo K,Lurhuma A,Sarin PS,Gallo RC,Zagury D

更新日期：1986-11-15 00:00:00

abstract：:Freshly isolated human peripheral blood monocytes from healthy volunteers are not cytotoxic to allogeneic A375 melanoma cells, but they were rendered tumoricidal by incubation in vitro with either liposomes containing 5 micrograms/mumol phospholipid of muramyl tripeptide phosphatidylethanolamine (liposome-MTP-PE; opti...

journal_title：International journal of cancer

authors： Sone S,Tandon P,Utsugi T,Ogawara M,Shimizu E,Nii A,Ogura T

更新日期：1986-10-15 00:00:00

abstract：:Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, from 114 monkeys in central Ethiopia in...

journal_title：International journal of cancer

authors： Dracopoli NC,Turner TR,Else JG,Jolly CJ,Anthony R,Gallo RC,Saxinger WC

更新日期：1986-10-15 00:00:00

abstract：:Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage c...

journal_title：International journal of cancer

authors： Lowenstine LJ,Pedersen NC,Higgins J,Pallis KC,Uyeda A,Marx P,Lerche NW,Munn RJ,Gardner MB

更新日期：1986-10-15 00:00:00

abstract：:The DNA configuration of the immunoglobulin (Ig) heavy and light chain genes and the expression of B-cell-related markers were evaluated in 13 cases of non-T, non-B, non-common ("null") acute lymphoblastic leukaemia (ALL). A rearrangement of the Ig heavy-chain gene was found in all cases studied; in 5 of these a struc...

journal_title：International journal of cancer

authors： Foa R,Migone N,Basso G,Cattoretti G,Pizzolo G,Lauria F,Casorati G,Giubellino MC,Capuzzo F,Cantù-Rajnoldi A

更新日期：1986-09-15 00:00:00

abstract：:A herpesvirus (RhEBV) was isolated from a lymphoblastoid cell line (LCL) that became established from a malignant lymphoma in a rhesus monkey. The predominant cell marker in the LCL was that of B lymphocytes. RhEBV-induced viral capsid (VCA) and nuclear antigens (NA) in the LCL were serologically related to similar an...

journal_title：International journal of cancer

authors： Rangan SR,Martin LN,Bozelka BE,Wang N,Gormus BJ

更新日期：1986-09-15 00:00:00

abstract：:A panel of 7 diagnostic cytopathologists, i.e., physicians trained to diagnose the malignant potential of human cells in Papanicolaou-stained smears, was asked to evaluate two sets of microscope slides of stained coverslip preparations of 28 cell culture lines, 15 of which were neoplastic. Slide Set I consisted of 13 ...

journal_title：International journal of cancer

authors： Boone CW,Sanford KK,Frost JK,Mantel N,Gill GW,Jones GM

更新日期：1986-09-15 00:00:00

abstract：:The monoclonal antibody (MAb) 4F2 defines an oncofetal antigen in human fibroblastic cells. Two-dimensional electrophoretic analysis reveals that tumor cell lines from mesenchymal tissues co-express two or more heavy-chain molecular variants of the antigen whereas the light subunit (41 kDa) is not affected. Among norm...

journal_title：International journal of cancer

authors： Azzarone B,Eid P,Malpiece Y,Andeol Y,Fauci AS,Suarez H

更新日期：1986-08-15 00:00:00

abstract：:The effect of the glycosylation inhibitor, tunicamycin, on synthesis and secretion of the membrane-associated glycoprotein carcinoembryonic antigen (CEA), was studied in the LS174T human colon cancer cell line. Tunicamycin treatment inhibited total cellular glycoprotein synthesis but did not affect CEA levels of cellu...

journal_title：International journal of cancer

authors： Miura S,Kim YS

更新日期：1986-08-15 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are widespread, chemically-stable environmental contaminants; some congeners are commonly found in human adipose tissue and breast milk. We investigated the effects of a single dose of one PCB mixture (Aroclor 1254) on tumors initiated by N-nitrosodimethylamine (NDMA), also a common en...

journal_title：International journal of cancer

authors： Anderson LM,Ward JM,Fox SD,Isaaq HJ,Riggs CW

更新日期：1986-07-15 00:00:00

abstract：:This work demonstrates the need for the continued presence of lipopolysaccharide (LPS) for tumor necrosis factor (TNF) production by thioglycollate-induced peritoneal macrophages. Removal of LPS at any time resulted in the abrupt cessation of further TNF production. The readdition of LPS resulted in further production...

journal_title：International journal of cancer

authors： Gifford GE,Lohmann-Matthes ML

更新日期：1986-07-15 00:00:00

abstract：:We have examined, in proliferating neoplastic cells, the effect on DNA of EGTA (a chelator of Ca2+) and W7 (an inhibitor of calmodulin). The treatment results in release of single-stranded DNA fragments (2-10 kb) from pre-labelled HMW DNA. When DNA from synchronized neoplastic cells in S phase is examined, almost all ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S

更新日期：1986-06-15 00:00:00

abstract：:The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...

journal_title：International journal of cancer

authors： Ishikawa M,Koga Y,Hosokawa M,Kobayashi H

更新日期：1986-06-15 00:00:00

abstract：:Fibrin deposition in the microenvironment of tumor cells may be critical to tumor growth and metastasis formation. Procoagulant activities of tumor cells themselves, or of infiltrating macrophages, activated by the host's immune system to the tumor, may both contribute to coagulopathies associated with metastases. Lym...

journal_title：International journal of cancer

authors： Geczy CL,Ryan J,Walsh J,Goldstein D

更新日期：1986-05-15 00:00:00

abstract：:Active, structurally unrelated tumor promoters (12-0-tetradecanoyl-phorbol-13-acetate (TPA), teleocidin and aplysiatoxin) inhibit growth of mammary carcinoma cells (MCF7- greater than BT-20 greater than MDA-MB-231 greater than = ZR-75-1 greater than HBL-100). This efficiency in inhibiting cell growth correlates with t...

journal_title：International journal of cancer

authors： Regazzi R,Fabbro D,Costa SD,Borner C,Eppenberger U

更新日期：1986-05-15 00:00:00

abstract：:DU-PAN-2 is a high-molecular-weight glycoprotein defined by a murine monoclonal antibody (MAb) against a pancreatic ductal adenocarcinoma cell line. In order to evaluate the usefulness of this antigen as a tumor marker, we determined the serum level of the antigen by competitive inhibition radioimmunoassay in sera fro...

journal_title：International journal of cancer

authors： Sawabu N,Toya D,Takemori Y,Hattori N,Fukui M

更新日期：1986-05-15 00:00:00

abstract：:Antibodies directed against idiotypic determinants of the cell-surface IgM of a B lymphoma, 38c, were effective in delaying development of the tumor and in some instances in preventing its growth. The efficacity of the anti-idiotype antibodies was markedly increased when they were injected in combination with anti-neo...

journal_title：International journal of cancer

authors： Hurwitz E,Burowski D,Kashi R,Hollander N,Haimovich J

更新日期：1986-05-15 00:00:00

abstract：:A panel of 7 mouse monoclonal antibodies and the lectin from Ulex europeus, detecting blood-group-related antigens of the ABH and Lewis systems, have been used to define the distribution of these antigenic structures within the human gastrointestinal tract, and to characterize their expression and modulation in colore...

journal_title：International journal of cancer

authors： Cordon-Cardo C,Lloyd KO,Sakamoto J,McGroarty ME,Old LJ,Melamed MR

更新日期：1986-05-15 00:00:00

abstract：:Fine-needle aspiration cytology (FNAC) is currently used in evaluating the nature of breast nodules. In the present study we have examined whether monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) can be employed in FNAC for the diagnosis of breast cancer. For this purpose we have used 2 murine M...

journal_title：International journal of cancer

authors： Nuti M,Mottolese M,Viora M,Donnorso RP,Schlom J,Natali PG

更新日期：1986-04-15 00:00:00

abstract：:Southern blot analyses of surgical specimens of cervical carcinoma from Japanese patients showed that 3/9 samples contained human papillomavirus (HPV) type-16 DNA sequences, and 2 contained HPV type-18 DNA sequences. By Northern blot analyses, RNA transcripts of HPV DNA sequences were demonstrated in some of the tissu...

journal_title：International journal of cancer

authors： Tsunokawa Y,Takebe N,Nozawa S,Kasamatsu T,Gissmann L,zur Hausen H,Terada M,Sugimura T

更新日期：1986-04-15 00:00:00

abstract：:Human epidermoid carcinoma A431 cells attach more rapidly to collagen type-I and -IV substrates than to surfaces coated with laminin or fibronectin. The diminished intercellular interaction and rounding up manifested when these cells are exposed to epidermal growth factor (EGF) in tissue culture plastic or collagen fi...

journal_title：International journal of cancer

authors： Rieber M,Gil F,Rieber MS,Urbina C

更新日期：1986-03-15 00:00:00

abstract：:Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...

journal_title：International journal of cancer

authors： English DR,Heenan PJ,Holman CD,Armstrong BK,Blackwell JB,Kelsall GR,Matz LR,Singh A,ten Seldam RE

更新日期：1986-02-15 00:00:00

abstract：:Two putative genes (termed pro 1 and pro 2) specifying sensitivity to induction of neoplastic transformation by TPA in mouse epidermal JB6 cells were cloned by sib selection from a size-selected genomic library of clonal cells sensitive to promotion of transformation. By restriction analysis, heteroduplex analysis, di...

journal_title：International journal of cancer

authors： Lerman MI,Hegamyer GA,Colburn NH

更新日期：1986-02-15 00:00:00

abstract：:The growth properties of a human melanoma cell line (MeWo) and of a variant (MeWo-LC1) endowed with higher metastatic potential in nude mice were compared using hormonally-defined serum-free media. The two cell lines failed to arrest in G0 following serum deprivation, and responded to INS and MSA but not to EGF, PDGF ...

journal_title：International journal of cancer

authors： Sauvaigo S,Fretts RE,Riopelle RJ,Lagarde AE

更新日期：1986-01-15 00:00:00

abstract：:In previous studies we showed that human sarcoma and melanoma cell lines synthesize and secrete into culture medium a glycoprotein, migrating in urea sodium dodecyl sulfate-polyacrylamide gel electrophoresis at Mr 140,000. It is not detected in cultures of the corresponding normal cells. Conditioned medium of the mela...

journal_title：International journal of cancer

authors： Bízik J,Vaheri A,Saksela O,Kalkkinen N,Meri S,Grófóva M

更新日期：1986-01-15 00:00:00

abstract：:We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...

journal_title：International journal of cancer

authors： Pathak DR,Speizer FE,Willett WC,Rosner B,Lipnick RJ

更新日期：1986-01-15 00:00:00

abstract：:The role of natural immune defense in the control of metastatic spread of tumor cells was evaluated by adapting an s.c.-grown, antigenic, but non-immunogenic rat fibrosarcoma (Bsp6S) to ascitic growth (BSp6A) in the strain of origin (BDX), where peritoneal cells display a high level of NK and macrophage activity. Para...

journal_title：International journal of cancer

authors： Zöller M

更新日期：1986-01-15 00:00:00

abstract：:Premature chromosome condensation (PCC) was studied in direct preparations of tissues from patients with haematological diseases and carcinomas of various histological types. PCC was found in 6 out of 166 malignancies (128 haematological cases, 35 carcinomas and 3 malignant effusions) analysed with the GTG-technique. ...

journal_title：International journal of cancer

authors： Kovacs G

更新日期：1985-12-15 00:00:00

abstract：:Conventionally bred rats possess in their sera an NA which has a cytotoxic effect on a tumor cell line (KMT-17) derived from a fibrosarcoma induced by 3-methylcholanthrene and which can be absorbed by normal rat tissues. We have succeeded in purifying a glycosphingolipid as an antigen reactive to NA. GSLs isolated fro...

journal_title：International journal of cancer

authors： Takimoto M,Suzuki E,Naiki M,Itaya T,Takeichi N,Hosokawa M,Kobayashi H

更新日期：1985-12-15 00:00:00